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We Research
the human
GUT Microbiome.

 
 
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Publications.

The Dynamic Microbial Landscape of the Intestine and its Impact on Probiotic Therapy

The Dynamic Microbial Landscape of the Intestine and its Impact on Probiotic Therapy.

Denise Chac and R. William DePaolo

– Journal of Probiotics and Health

Infection, genetics & inflammation set the stage for chronic inflammation

Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease.

Karishma Kamdar, Samira Khakpour, Jingyu Chen, Vanessa Leone, Jennifer Brulc, Thomas Mangatu, Dionysios A. Antonopoulos, Eugene B. Chang, Stacy A. Kahn, Barbara S. Kirschner, Glenn Young, R. William DePaolo

– Cell Host & Microbe

Intestinal inflammation can be worsened by vitamin A (Celiac disease)

Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens.

DePaolo RW, Abadie V, Tang F, Fehlner-Peach H, Hall JA, Wang W, Marietta EV, Kasarda DD, Waldmann TA, Murray JA, Semrad C, Kupfer SS, Belkaid Y, Guandalini S, Jabri B

– Nature

 
 
 

mission.

The mission of DePaolo Lab is to identify environmental factors that impact distinct ecological communities in the human gut microbiome and to develop therapies to maintain or restore ecological harmony, and to always encourage and guide our team to think critically, practice good science and think outside of the box.

 
 
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