The Dynamic Microbial Landscape of the Intestine and its Impact on Probiotic Therapy

Denise Chac and William R DePaolo -  The Dynamic Microbial Landscape of the Intestine and its Impact on Probiotic Therapy
– Journal of Probiotics and Health - Omics International


INfection, genetics & inflammation set the stage for chronic inflammation

Karishma Kamdar, Samira Khakpour, Jingyu Chen, Vanessa Leone, Jennifer Brulc, Thomas Mangatu, Dionysios A. Antonopoulos, Eugene B. Chang, Stacy A. Kahn, Barbara S. Kirschner, Glenn Young, R. William DePaolo – Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease
– Cell Host & Microbe - PubMed 


Intestinal inflammation can be worsened by vitamin A
(Celiac disease)

DePaolo RW,Abadie V,Tang F,Fehlner-Peach H,Hall JA,Wang W,Marietta EV,Kasarda DD,Waldmann TA,Murray JA,Semrad C,Kupfer SS,Belkaid Y,Guandalini S,Jabri B – Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens.
– Nature -PubMed



Delayed DC Migration Impact on Multiple Sclerosis

Elhofy A,Depaolo RW,Lira SA,Lukacs NW,Karpus WJ – Mice deficient for CCR6 fail to control chronic experimental autoimmune encephalomyelitis.
J Neuroimmunol -PubMed



Immune evasion by plague

DePaolo RW,Tang F,Kim I,Han M,Levin N,Ciletti N,Lin A,Anderson D,Schneewind O,Jabri B – Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis.
Cell Host & Microbe -PubMed



Protective Immunity in bubonic and pneumonic plague by modified plague vaccine

DeBord KL,Anderson DM,Marketon MM,Overheim KA,DePaolo RW,Ciletti NA,Jabri B,Schneewind O – Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV.
Infect Immun -PubMed



Plague bacteria target immune cells during infection

 Marketon MM,DePaolo RW,DeBord KL,Jabri B,Schneewind O – Plague bacteria target immune cells during infection.
Science -PubMed



Chemokines and diarrea infection

DePaolo RW,Lathan R,Rollins BJ,Karpus WJ – The chemokine CCL2 is required for control of murine gastric Salmonella enterica infection.
Infect Immun -PubMed



Generation of a modified plague vaccine

Overheim KA,Depaolo RW,Debord KL,Morrin EM,Anderson DM,Green NM,Brubaker RR,Jabri B,Schneewind O – LcrV plague vaccine with altered immunomodulatory properties.
Infect Immun -PubMed



Regulation of oral tolerance via chemokine-chemokine interactions

DePaolo RW,Lathan R,Karpus WJ – CCR5 regulates high dose oral tolerance by modulating CC chemokine ligand 2 levels in the GALT.
– J Immunol -PubMed



Role of the chemokine CCL2 in oral tolerance

DePaolo RW,Rollins BJ,Kuziel W,Karpus WJ – CC chemokine ligand 2 and its receptor regulate mucosal production of IL-12 and TGF-beta in high dose oral tolerance.
– J Immunol -PubMed