The Dynamic Microbial Landscape of the Intestine and its Impact on Probiotic Therapy

The Dynamic Microbial Landscape of the Intestine and its Impact on Probiotic Therapy.

Denise Chac and R. William DePaolo

Journal of Probiotics and Health

Delayed DC Migration Impact on Multiple Sclerosis

Mice deficient for CCR6 fail to control chronic experimental autoimmune encephalomyelitis.

Elhofy A, Depaolo RW, Lira SA, Lukacs NW, Karpus WJ

– Journal of Neuroimmunology

Plague bacteria target immune cells during infection

Plague bacteria target immune cells during infection.

 Marketon MM, DePaolo RW, DeBord KL, Jabri B, Schneewind O

– Science

Regulation of oral tolerance via chemokine-chemokine interactions

CCR5 regulates high dose oral tolerance by modulating CC chemokine ligand 2 levels in the GALT.

DePaolo RW, Lathan R, Karpus WJ

– Journal of Immunology

Infection, genetics & inflammation set the stage for chronic inflammation

Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease.

Karishma Kamdar, Samira Khakpour, Jingyu Chen, Vanessa Leone, Jennifer Brulc, Thomas Mangatu, Dionysios A. Antonopoulos, Eugene B. Chang, Stacy A. Kahn, Barbara S. Kirschner, Glenn Young, R. William DePaolo

– Cell Host & Microbe

Immune evasion by plague

Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis.

DePaolo RW, Tang F,Kim I,Han M,Levin N, Ciletti N, Lin A, Anderson D, Schneewind O, Jabri B

– Cell Host & Microbe

Chemokines and diarrhea infection

DePaolo RW, Lathan R,Rollins BJ, Karpus WJ – The chemokine CCL2 is required for control of murine gastric Salmonella enterica infection.

– Infection and Immunity

Role of the chemokine CCL2 in oral tolerance

CC chemokine ligand 2 and its receptor regulate mucosal production of IL-12 and TGF-beta in high dose oral tolerance.

DePaolo RW, Rollins BJ, Kuziel W, Karpus WJ

– Journal of Immunology

Intestinal inflammation can be worsened by vitamin A (Celiac disease)

Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens.

DePaolo RW, Abadie V, Tang F, Fehlner-Peach H, Hall JA, Wang W, Marietta EV, Kasarda DD, Waldmann TA, Murray JA, Semrad C, Kupfer SS, Belkaid Y, Guandalini S, Jabri B


Protective Immunity in bubonic and pneumonic plague by modified plague vaccine

Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV.

DeBord KL, Anderson DM, Marketon MM, Overheim KA, DePaolo RW, Ciletti NA, Jabri B, Schneewind O

– Infection and Immunity

Generation of a modified plague vaccine

LcrV plague vaccine with altered immunomodulatory properties.

Overheim KA, Depaolo RW, Debord KL, Morrin EM, Anderson DM, Green NM, Brubaker RR, Jabri B, Schneewind O

– Infection and Immunity