Inflammatory Bowel Disease (IBD) & Associated Cancers.

 
 

Clinical microbiome repository

The relationship we have with our gut bacteria is a give and take. While much research is interested in how the microbiome is changing our bodies, we can forget that we also exert an enormous amount of influence on our microbial counterparts. From diet, to pollution, to antibiotic use, we are constantly exposing the microbiome with factors that could induce changes in their metabolism or function that may have detrimental effects on our health.

Focusing on IBD, we will be isolating, tracking and analyzing specific fecal bacteria from patients over the course of their disease. This will allow clinicians and researchers to pair these bacterial studies with patient response to treatments, disease pathology and inflammation bringing a new meaning to Personalized Medicine.

Inflammation-associated and sporadic colon cancers

Our group has discovered a gene that may make cells more sensitive to chemotherapy and is associated with longer progression free and overall survival in patients with colon cancer.

Current research is focused on identifying the pathways involved in this process. Our goal is to create microbiome-associated biotherapeutics that could increase the efficacy of chemotherapy.

Related Publications

Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease.

- Cell Host & Microbe

 
 
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Patrice Pardino
Undergraduate Student, USC
DePaolo Lab alum